5,801 research outputs found
Biogeographic analysis of the Tortugas Ecological Reserve: Examining the refuge effect following reserve establishment
Almost 120 days at sea aboard three NOAA research vessels and one fishing vessel over the past three years have supported biogeographic characterization of Tortugas Ecological Reserve (TER). This work initiated measurement of post-implementation effects of TER as a refuge for exploited species. In Tortugas South, seafloor transect surveys were conducted using divers, towed operated vehicles (TOV), remotely operated vehicles (ROV), various sonar platforms, and the Deepworker manned submersible.
ARGOS drifter releases, satellite imagery, ichthyoplankton surveys, sea surface temperature, and diver census were combined to elucidate potential dispersal of fish spawning in this environment. Surveys are being compiled into a GIS to allow resource managers to gauge benthic resource status and distribution. Drifter studies have determined that within the ~ 30 days of larval life stage for fishes spawning at Tortugas South, larvae could reach as far downstream as Tampa Bay on the west Florida coast and Cape
Canaveral on the east coast. Together with actual fish surveys and water mass delineation, this work demonstrates that the refuge status of this area endows it with tremendous downstream spillover and larval export potential for Florida reef habitats and promotes the maintenance of their fish communities.
In Tortugas North, 30 randomly selected, permanent stations were established. Five stations were assigned to each of the following six areas: within Dry Tortugas National Park, falling north of the prevailing currents (Park North); within Dry Tortugas National Park, falling south of the prevailing currents (Park South); within the Ecological Reserve falling north of the prevailing currents (Reserve
North); within the Ecological Reserve falling south of the prevailing currents (Reserve South); within areas immediately adjacent to these two strata, falling north of the prevailing currents (Out North); and within areas immediately adjacent to these two strata, falling south of the prevailing currents (Out South). Intensive characterization of these sites was conducted using multiple sonar techniques, TOV, ROV, diver-based digital video collection, diver-based fish census, towed fish capture, sediment particle-size, benthic chlorophyll analyses, and stable isotope analyses of primary producers, fish, and, shellfish. In order to complement and extend information from studies focused on the coral reef, we have
targeted the ecotone between the reef and adjacent, non-reef habitats as these areas are well-known in ecology for indicating changes in trophic relationships at the ecosystem scale. Such trophic changes are hypothesized to occur as top-down control of the system grows with protection of piscivorous fishes. Preliminary isotope data, in conjunction with our prior results from the west Florida shelf, suggest that the shallow water benthic habitats surrounding the coral reefs of TER will prove to be the source of a significant amount of the primary production ultimately fueling fish production throughout TER and
downstream throughout the range of larval fish dispersal. Therefore, the status and influence of the previously neglected, non-reef habitat within the refuge (comprising ~70% of TER) appears to be intimately tied to the health of the coral reef community proper.
These data, collected in a biogeographic context, employing an integrated Before-After Control Impact design at multiple spatial scales, leave us poised to document and quantify the postimplementation effects of TER. Combined with the work at Tortugas South, this project represents a
multi-disciplinary effort of sometimes disparate disciplines (fishery oceanography, benthic ecology, food
web analysis, remote sensing/geography/landscape ecology, and resource management) and approaches (physical, biological, ecological). We expect the continuation of this effort to yield critical information for the management of TER and the evaluation of protected areas as a refuge for exploited species. (PDF contains 32 pages.
Simvastatin impairs the induction of pulmonary fibrosis caused by a western style diet: A preliminary study
The role of an atherogenic diet in causing pulmonary fibrosis has received little attention and simvastatin has been shown to reduce pulmonary fibrosis in animal models. To determine if an atherogenic diet can induce pulmonary fibrosis and whether simvastatin treatment is beneficial by up-regulating heat shock protein 70 and 90. New Zealand white rabbits (n = 15) were divided: Group 1 (control); Group 2 (MC) received a normal rabbit diet with 1% methionine plus 0.5% cholesterol (atherogenic diet). Group 3 received the same diet as the MC group plus 5 mg/kg/day simvastatin orally (MCS). After 4 weeks, the lungs were collected and analysed. Picrosirus red staining of lung interstitial collagen content showed that the atherogenic diet increased fibrosis 2.9-fold (P < 0.05), bronchiole adventitial collagen was increased 2.3-fold (P < 0.05) and bronchiole epithelium was increased 34-fold (P < 0.05), and simvastatin treatment severely reduced this effect (P < 0.05). Western blot analysis showed that the atherogenic diet significantly reduced lung Hsp70 protein by 22% (P < 0.05) and Hsp90 protein by 18% (P < 0.05) and simvastatin treatment did not affect this result. However, aortic hyper-responsiveness to vasoconstrictors (angiotensin II and phenylephrine) were markedly reduced by simvastatin treatment. We report that an atherogenic diet stimulates pulmonary fibrosis and reduces lung Hsp70/Hsp90 protein concentration. Simvastatin impairs this by mechanisms unrelated to Hsp70/Hsp90, but possibly a reduction in angiotensin II receptor or alpha adrenergic receptor pathways. These results could have implications in idiopathic pulmonary fibrosis
Multi-wavelength observations of 2HWC J1928+177: dark accelerator or new TeV gamma-ray binary?
2HWC J1928+177 is a Galactic TeV gamma-ray source detected by the High
Altitude Water Cherenkov (HAWC) Observatory up to ~ 56 TeV. The HAWC source,
later confirmed by H.E.S.S., still remains unidentified as a dark accelerator
since there is no apparent supernova remnant or pulsar wind nebula detected in
the lower energy bands. The radio pulsar PSR J1928+1746, coinciding with the
HAWC source position, has no X-ray counterpart. Our SED modeling shows that
inverse Compton scattering in the putative pulsar wind nebula can account for
the TeV emission only if the unseen nebula is extended beyond r ~ 4 [arcmin].
Alternatively, TeV gamma rays may be produced by hadronic interactions between
relativistic protons from an undetected supernova remnant associated with the
radio pulsar and a nearby molecular cloud G52.9+0.1. NuSTAR and Chandra
observations detected a variable X-ray point source within the HAWC error
circle, potentially associated with a bright IR source. The X-ray spectra can
be fitted with an absorbed power-law model with cm and and exhibit
long-term X-ray flux variability over the last decade. If the X-ray source,
possibly associated with the IR source (likely an O star), is the counterpart
of the HAWC source, it may be a new TeV gamma-ray binary powered by collisions
between the pulsar wind and stellar wind. Follow-up X-ray observations are
warranted to search for diffuse X-ray emission and determine the nature of the
HAWC source.Comment: accepted to ApJ, 8 pages, 7 figure
Bounding the graviton mass with binary pulsar observations
By comparing the observed orbital decay of the binary pulsars PSRB1913+16 and
PSRB1534+12 to that predicted by general relativity due to gravitational-wave
emission, we are able to bound the mass of the graviton to be less than
at 90% confidence. This is the first such
bound to be derived from dynamic gravitational fields. It is approximately two
orders of magnitude weaker than the static-field bound from solar system
observations, and will improve with further observations.Comment: 9 pages, 1 figure. Presented at Fourth Edoardo Amaldi Conference on
Gravitational Waves, Perth, 200
Plane-Symmetric Inhomogeneous Bulk Viscous Cosmological Models with Variable
A plane-symmetric non-static cosmological model representing a bulk viscous
fluid distribution has been obtained which is inhomogeneous and anisotropic and
a particular case of which is gravitationally radiative. Without assuming any
{\it adhoc} law, we obtain a cosmological constant as a decreasing function of
time. The physical and geometric features of the models are also discussed.Comment: 11 page
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Revealing What Urban Early Childhood Teachers Think About Mathematics and How They Teach It: Implications for Practice
Hersh (1986) states, "One's conception of what mathematics is affects one's conception of how it should be presented. One's manner of presenting it is an indication of what one believes to be most essential in it." In this research study, three hundred ninety-seven urban early childhood teachers were given a survey that examined their attitudes toward mathematics and mathematics teaching, their views of mathematics, views of teaching mathematics, and views of children learning mathematics. The purpose of this study was to identify the attitudes and beliefs of early childhood teachers in two urban school districts to determine if mathematics reform efforts made a difference in teachers' attitudes and beliefs about mathematics and its teaching. Questionnaires were mailed directly to teachers in one school district and principals distributed questionnaires in the other. Summary scores were calculated for parts of the instrument. The researcher performed descriptive statistics, comparative analysis, and conducted frequency distributions, t-tests, ANOVA, and Pearson Correlations. Findings revealed that teachers with 30 or more years of teaching experience had more positive attitudes toward mathematics than teachers with 1-3 years of experience. African American teachers had more positive attitudes toward mathematics and its teaching than other ethnic groups. Teachers who held a minor or major in mathematics had more positive attitudes toward mathematics and its teaching than teachers without a minor or major in mathematics. Teachers in District-A favored constructivist learning while teachers in District-B favored rote learning. Both school districts' teachers favored the problem-solving approach to teaching mathematics. If instruction is to be transformed, reformers need to understand teachers' beliefs about mathematics. Beliefs, which are essential for teachers' development, seldom change without significant intervention (Lappan and Theule-Lubienski, 1994). Therefore, school districts must be informed about the changes necessary for the reform of mathematics teaching and identify and implement through staff developments and other measures what they perceive mathematics to be and how it should be taught
Structural organisation of the type IV secretion systems
Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNAs and/or proteins through the membranes of bacteria. Because of their complexity and multi-protein organisation, T4S systems have been extremely challenging to study structurally. However in the past five years significant milestones have been achieved by X-ray crystallography and cryo-electron microscopy. This review describes some of the more recent advances: the structures of some of the protein components of the T4S systems and the complete core complex structure that was determined using electron microscopy
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Actions and Potential Therapeutic Applications of Growth Hormone-Releasing Hormone Agonists.
Abstract
In this article, we briefly review the identification of GHRH, provide an abridged overview of GHRH antagonists, and focus on studies with GHRH agonists. Potent GHRH agonists of JI and MR class were synthesized and evaluated biologically. Besides the induction of the release of pituitary GH, GHRH analogs promote cell proliferation and exert stimulatory effects on various tissues, which express GHRH receptors (GHRH-Rs). A large body of work shows that GHRH agonists, such as MR-409, improve pancreatic β-cell proliferation and metabolic functions and facilitate engraftment of islets after transplantation in rodents. Accordingly, GHRH agonists offer a new therapeutic approach to treating diabetes. Various studies demonstrate that GHRH agonists promote repair of cardiac tissue, producing improvement of ejection fraction and reduction of infarct size in rats, reduction of infarct scar in swine, and attenuation of cardiac hypertrophy in mice, suggesting clinical applications. The presence of GHRH-Rs in ocular tissues and neuroprotective effects of GHRH analogs in experimental diabetic retinopathy indicates their possible therapeutic applications for eye diseases. Other effects of GHRH agonists, include acceleration of wound healing, activation of immune cells, and action on the central nervous system. As GHRH might function as a growth factor, we examined effects of GHRH agonists on tumors. In vitro, GHRH agonists stimulate growth of human cancer cells and upregulate GHRH-Rs. However, in vivo, GHRH agonists inhibit growth of human cancers xenografted into nude mice and downregulate pituitary and tumoral GHRH-Rs. Therapeutic applications of GHRH analogs are discussed. The development of GHRH analogs should lead to their clinical use
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